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【特徴】背景：Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities thereby playing a role in glycolysis and nuclear functions respectively. Participates in nuclear events including transcription RNA transport DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1 HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.【仕様】種由来：Human発現宿主：E.coli純度：>90% as determined by reducing SDS-PAGE.遺伝子構造：A DNA sequence encoding the Human GAPDH (P04406) (1M-333E) was expressed with a polyhistidine tag at the N-terminus.別名（遺伝子名）：Aging associated gene 9 proteinEpididymis secretory sperm binding protein Li 162ePG3PG3PDG3PDHGAPDGAPDHGlyceraldehyde 3 phosphate dehydrogenaseGlyceraldehyde-3-phosphate dehydrogenaseHEL S 162ePPeptidyl-cysteine S-nitrosylase GAPDHアミノ酸配列：1M-333EアクセッションＮｏ．：P04406タグ種類：N/C-Hisエンドトキシン濃度：Not tested.分子量：37.1kDa組成：Lyophilized from sterile PBS pH 7.4保存条件：Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.メーカーマニュアルリンク：https://u2.elabscience.com/viewpdf-447171-elabscience-PKSH500005.pdfサイズ：100ugこの商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
更新日2025年04月18日/登録日2024年10月06日
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